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Variant Effects

This page provides links to Sorting Intolerant From Tolerant (SIFT) and Variant Effect Predictor (VEP) to predict whether an amino acid substitution affects protein function.
SIFT missense predictions for genomes: Nature Protocols 2016; 11:1-9. The Ensembl Variant Effect Predictor: Genome Biology Jun 6;17(1):122. (2016) doi:10.1186/s13059-016-0974-4.

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In 2009 the Toronto International Data Release Workshop agreed on a policy statement about prepublication data sharing. Accordingly, the data producers are making many of the datasets in T3 available prior to publication of a global analysis. Guidelines for appropriate sharing of these data are given in the excerpt from the Toronto Statement

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